IQVIA CORE Diabetes Model Version 9.5

Dear Core Diabetes Model User,

We are very happy to announce the launch of version 9.5 of the IQVIA Core Diabetes Model.

This version of the model comes with several new features:

  • An uploadable excel as an alternative to populating the different settings online, you may now complete the following modules in an excel template and upload it in a couple of seconds:
    • Cohort
    • Economics
    • Treatment
    • Management
    • Mortality tables
  • Updated default values for Clinical settings, available to all users
  • New cardiovascular risk equations:
    • Swedish National Diabetes Registry for type 1
    • Four Asian risk equations in type 2
    • An alternative Framingham equation
  • Progression of physiological parameters based on Swedish National Diabetes Registry
  • Simplified foot ulcer sub-model
  • Updated renal disease progression parameters
  • Replacement of lactic acidosis as adverse event by three placeholder treatment-specific adverse events
  • Replacement of depression sub-model by a placeholder complication sub-model
  • Possibility to relate hypoglycemic events to cardiovascular events and mortality
  • An adherence module that links adherence to a drug below 100% with decreased treatment impact on HbA1c and BMI.
  • BMI disutility applicable via static approach (with a single data input) or a polynomial function
  • Relative risk reduction on cardiovascular and renal events, allowing model calibration for cardiovascular outcomes trials

The many updates done to the model and its inputs obliged us to start with a new empty database. Therefore, settings from version 9.0 cannot be migrated to version 9.5. However, with the uploadable excel this should not cause you any delays (to the contrary).

We hope you are as excited as we are about this new version of the IQVIA Core Diabetes Model, and we are happy to tell you more about all the changes and implications. For that, we are working on a reference manual for version 9.5 where all inputs will be documented.

Please note that there are at the moment no plans to decommission version 9.0 of the CDM. It should at least be available until the end of 2021.

With the kindest regards

Mark Lamotte
For the CDM team

IQVIA CORE Diabetes Model at ISPOR 2019 US

Dear IQVIA Core Diabetes Model User,

Since March 19 the IQVIA CDM has been available with a new user interface under the E360 platform. By the end of Q2 2019 we are also expecting to launch version 9.5 of the CDM. This new version will have several new features.
During the upcoming ISPOR conference in New Orleans (May 20-22 2019) the IQVIA CDM team will be present to provide demo presentations on the new platform and on the new features of version 9.5.
Please book your time with us by e-mailing or
Don’t hesitate to forward this e-mail to your colleagues that are participating in the conference!

Also note that we will present 5 posters talking about the new features of version 9.5 at this conference as outlined hereunder.

Monday, May 20, 2019
3:30 PM - 7:00 PM

Monteiro S, Ramos M, Altrabsheh E, Gurjar K, Olivieri A, Lamotte M. Contrasting Framingham Risk Equations in Type 2 Diabetes Using the IQVIA Core Diabetes Model. Submitted to ISPOR 24th Annual International Meeting New Orleans US, May 18-22 2019. PDB35

Olivieri A, Ramos M, Monteiro S, Altrabsheh E, Gurjar K, Lamotte M. CONTRASTING THREE TYPE 2 DIABETES CARDIOVASCULAR RISK EQUATIONS FOR EAST ASIA WITH UKPDS82 USING THE IQVIA CORE DIABETES MODEL. Submitted to ISPOR 24th Annual International Meeting New Orleans US, May 18-22 2019. PDB26

Ramos M, Olivieri A, Monteiro S, Altrabsheh E, Gurjar K, Lamotte M. BODY MASS INDEX ASSOCIATED UTILITY APPROACHES IN THE IQVIA CORE DIABETES MODEL. Submitted to ISPOR 24th Annual International Meeting New Orleans US, May 18-22 2019. PDB23

Gurjar K, Ramos M, Monteiro S, Altrabsheh E, Olivieri A, Lamotte M. Comparability of results using two alternative versions of the IQVIA CORE Diabetes Model. Submitted to ISPOR 24th Annual International Meeting New Orleans US, May 18-22 2019. PDB30

Altrabsheh E, Monteiro S, Ramos M, Gurjar K, Olivieri A, Lamotte M. Association Between Cardiovascular Disease Risk Factors and Hypoglycaemic events in Type 2 Diabetes Using the IQVIA Core Diabetes Model Submitted to ISPOR 24th Annual International Meeting New Orleans US, May 18-22 2019. PDB64

Looking forward to see you in New Orleans.

With the kindest regards

For the CDM team
Mark Lamotte

Core Diabetes Model E360 Platform Release

Dear IQVIA Core Diabetes Model User,

We are pleased to announce that the IQVIA Core Diabetes Model has been successfully integrated into the IQVIA E360 platform. Thank you for your patience during this process.

Users can gain access to the E360 platform by clicking the E360 logo, found where the CDM log-in link was formerly located on the CDM webpage.

At this point, clicking “Forgotten your Login?” and entering the email address associated with your CDM user account will lead to an access credential retrieval email being sent to you. This will provide everything necessary to obtain access.

If your email is for any reason invalid, or you lack a registered email for the CDM, please do not hesitate to contact us at Thank you very much for your time.

Kind Regards,

The IQVIA Core Diabetes Model Team

IQVIA CORE Diabetes Model update

Dear IQVIA CORE Diabetes model users,

IQVIA are pleased to inform all users that we will release the updated 64bit version of IQVIA CORE Diabetes Model (CDM) version 9.0 and version 8.5 by March 17 2017.

The transition to the updated 64 bit CDM infrastructure is part of a continued development programme to ensure that the CDM is hosted and processed on current state-of-the-art technology and software. This upgrade is associated with a number of benefits which are outlined below.

Simulation time – The number of simultaneous simulations that can be processed on the simulation severer system has been increased more than threefold which will considerably reduce the overall waiting time until simulation results can be accessed.

Stability – Recently an increasing number of simulation crashes have been observed (simulations being interrupted during execution and requiring restart) which contributed to the elongation of waiting time until outcomes can be accessed. With the upgrade to the new system it is expected that the stability of simulation processes will be substantially improved.

Security – The technologies used by 64bit CDM allow improvement to the security of the environment on which new CDM system is built. It will allow the development and deployment of resolutions to newly discovered threats as well as ensuring improved safety and integrity of data. SSL encryption of all communication between the user and web interface mean that all sensitive settings and simulation data will remain protected from outside interference and theft.

With this background information we kindly advise all CDM users to start using the new 64bit CDM versions as soon as possible.

The following URL link to the new 64bit CDM version can be used:

64bit CDM
CDM v9.0 and CDM v8.5:

The new versions will be fully equivalent to the current (32 bit) versions with the below exceptions:

  • Due to the change to the 64bit infrastructure, the randomness of simulations has changed which means that simulations that are executed on the new system will present slight (random) deviations towards outcomes generated on the current versions. The magnitude of random variability is dependent on the simulation size (i.e. declines with increasing number of patients and/or bootstrap iterations included).
  • The web interface appearance has changed slightly. Since the upgrade to 64 bit required a reimplementation of the web code, we took advantage of this update to change particular features which are explained in the attached update guide.
To avoid having to replicate all the work you have done for example for an ongoing submission, the 32Bit version remains still available for some time.

To access the 32bit versions, please use the following URL links:
32bit CDM
CDM v9.0:
CDM v8.5:

IQVIA CORE Diabetes Model User Group Forum

Dear CDM user,

The IQVIA Core Diabetes Model team will be at ISPOR in Milan in November, if you would like to attend a workshop on Sunday 8th November to find out more about the model please contact Mike Gains

Meeting Agenda

  • Introduction to version 9.0 of the model
  • Hypoglycaemic event module
  • New type 2 risk equations
  • Completely new Type 1 inputs based on new equations
  • NICE comments on version 8.5 and how they are addressed in version 9
  • Assessing the impact of BMI on cost-effectiveness
  • FAQ’s on the CDM

If you already use the model and have any questions regarding the analyses you are running please send all your questions and remarks to

Mark Lamotte
Senior Principal - Cardiologist
Real-World Evidence Solutions & HEOR


IQVIA CORE Diabetes Model Version 9.0

Dear user,

On July 13 2015 we launched version 9.0 of the CDM.
This updated version includes additional risk equation, a new module on hypoglycaemia, a complete rework of type 1 diabetes including the most recent available information, as well as a revised user interface.

If you want to use version 9.0 please click here

If you want to continue using version 8.5 please click here

Version 9.0 has been thoroughly tested however this does not exclude that there are still errors. Please e-mails us at if you face any issue.

Looking forward to hear from you,

Mark Lamotte, MD

Scientific Leader CDM

A tool for policy analysis and reimbursement strategy in diabetes

The IQVIA CORE Diabetes Model (IQVIA CDM) simulates disease progression in both type 1 and type 2 diabetes. The model is a tool that can be used to explore economic value over the course of a product’s lifecycle. Potential applications include identification of clinical development priorities, pricing evaluation, health technology assessment and post-launch market access support. The IQVIA CDM is a computer simulation model designed to take surrogate endpoints and translate them in to long term health economic outcomes:

The IQVIA CDM is the most widely adopted economic model in diabetes available to users from academia, and health care industries, as well as health care payers and decision makers.

  • The model has undergone an extensive validation process.
  • It is continually updated to include the latest clinical and epidemiological data as well as to implement functional improvements.
  • Results from the model have been widely published, with over 80 peer-reviewed publications.
  • 7 of the 10 largest diabetes drug and device manufacturers are using the CDM.

Find out how our team can help.

Additional Information

IQVIA CORE Diabetes Model is an IQVIA online application.
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