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QuintilesIMS Core Diabetes Model

QuintilesIMS CORE Diabetes Model update

Dear QuintilesIMS CORE Diabetes model users,

QuintilesIMS are pleased to inform all users that we will release the updated 64bit version of QuintilesIMS CORE Diabetes Model (CDM) version 9.0 and version 8.5 by March 17 2017.

The transition to the updated 64 bit CDM infrastructure is part of a continued development programme to ensure that the CDM is hosted and processed on current state-of-the-art technology and software. This upgrade is associated with a number of benefits which are outlined below.

Simulation time – The number of simultaneous simulations that can be processed on the simulation severer system has been increased more than threefold which will considerably reduce the overall waiting time until simulation results can be accessed.

Stability – Recently an increasing number of simulation crashes have been observed (simulations being interrupted during execution and requiring restart) which contributed to the elongation of waiting time until outcomes can be accessed. With the upgrade to the new system it is expected that the stability of simulation processes will be substantially improved.

Security – The technologies used by 64bit CDM allow improvement to the security of the environment on which new CDM system is built. It will allow the development and deployment of resolutions to newly discovered threats as well as ensuring improved safety and integrity of data. SSL encryption of all communication between the user and web interface mean that all sensitive settings and simulation data will remain protected from outside interference and theft.

With this background information we kindly advise all CDM users to start using the new 64bit CDM versions as soon as possible.

The following URL link to the new 64bit CDM version can be used:

64bit CDM
CDM v9.0 and CDM v8.5: https://www.core-diabetes.com

The new versions will be fully equivalent to the current (32 bit) versions with the below exceptions:

  • Due to the change to the 64bit infrastructure, the randomness of simulations has changed which means that simulations that are executed on the new system will present slight (random) deviations towards outcomes generated on the current versions. The magnitude of random variability is dependent on the simulation size (i.e. declines with increasing number of patients and/or bootstrap iterations included).
  • The web interface appearance has changed slightly. Since the upgrade to 64 bit required a reimplementation of the web code, we took advantage of this update to change particular features which are explained in the attached update guide.
To avoid having to replicate all the work you have done for example for an ongoing submission, the 32Bit version remains still available for some time.

To access the 32bit versions, please use the following URL links:
32bit CDM
CDM v9.0: http://www.core-diabetes.com:8080/login.asp
CDM v8.5: http://www.core-diabetes.com:8080/CDM2012/login.asp

IMS CORE Diabetes Model User Group Forum

Dear CDM user,

The IMS Core Diabetes Model team will be at ISPOR in Milan in November, if you would like to attend a workshop on Sunday 8th November to find out more about the model please contact Mike Gains

Meeting Agenda

  • Introduction to version 9.0 of the model
  • Hypoglycaemic event module
  • New type 2 risk equations
  • Completely new Type 1 inputs based on new equations
  • NICE comments on version 8.5 and how they are addressed in version 9
  • Assessing the impact of BMI on cost-effectiveness
  • FAQ’s on the CDM

If you already use the model and have any questions regarding the analyses you are running please send all your questions and remarks to mlamotte@be.imshealth.com

Mark Lamotte
Senior Principal - Cardiologist
Real-World Evidence Solutions & HEOR
IMS Health

CDM USER FORUM - ISPOR Milan 2015

IMS CORE Diabetes Model Version 9.0

Dear user,

On July 13 2015 we launched version 9.0 of the CDM.
This updated version includes additional risk equation, a new module on hypoglycaemia, a complete rework of type 1 diabetes including the most recent available information, as well as a revised user interface.

If you want to use version 9.0 please click here www.core-diabetes.com

If you want to continue using version 8.5 please click here www.core-diabetes.com/cdm2012

Version 9.0 has been thoroughly tested however this does not exclude that there are still errors. Please e-mails us at info_CDM@imshealth.com if you face any issue.

Looking forward to hear from you,

Mark Lamotte, MD

Scientific Leader CDM

A tool for policy analysis and reimbursement strategy in diabetes

The IMS CORE Diabetes Model (IMS Health CDM) simulates disease progression in both type 1 and type 2 diabetes. The model is a tool that can be used to explore economic value over the course of a product’s lifecycle. Potential applications include identification of clinical development priorities, pricing evaluation, health technology assessment and post-launch market access support. The IMS Health CDM is a computer simulation model designed to take surrogate endpoints and translate them in to long term health economic outcomes:

The IMS Health CDM is the most widely adopted economic model in diabetes available to users from academia, and health care industries, as well as health care payers and decision makers.

  • The model has undergone an extensive validation process.
  • It is continually updated to include the latest clinical and epidemiological data as well as to implement functional improvements.
  • Results from the model have been widely published, with over 80 peer-reviewed publications.
  • 7 of the 10 largest diabetes drug and device manufacturers are using the CDM.

Click here to access to your CDM 64bit account.

Click here to access to your CDM 32bit account.

Find out how our team can help.

Additional Information

QuintilesIMS CORE Diabetes Model is an QuintilesIMS online application.
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