QuintilesIMS CORE Diabetes Model update
Dear QuintilesIMS CORE Diabetes model users,
QuintilesIMS are pleased to inform all users that we will release the updated 64bit version of QuintilesIMS CORE Diabetes Model (CDM) version 9.0 and version 8.5 by March 17 2017.
The transition to the updated 64 bit CDM infrastructure is part of a continued development programme to ensure that the CDM is hosted and processed on current state-of-the-art technology and software. This upgrade is associated with a number of benefits which are outlined below.
Simulation time – The number of simultaneous simulations that can be processed on the simulation severer system has been increased more than threefold which will considerably reduce the overall waiting time until simulation results can be accessed.
Stability – Recently an increasing number of simulation crashes have been observed (simulations being interrupted during execution and requiring restart) which contributed to the elongation of waiting time until outcomes can be accessed. With the upgrade to the new system it is expected that the stability of simulation processes will be substantially improved.
Security – The technologies used by 64bit CDM allow improvement to the security of the environment on which new CDM system is built. It will allow the development and deployment of resolutions to newly discovered threats as well as ensuring improved safety and integrity of data. SSL encryption of all communication between the user and web interface mean that all sensitive settings and simulation data will remain protected from outside interference and theft.
With this background information we kindly advise all CDM users to start using the new 64bit CDM versions as soon as possible.
The following URL link to the new 64bit CDM version can be used:
CDM v9.0 and CDM v8.5: https://www.core-diabetes.com
The new versions will be fully equivalent to the current (32 bit) versions with the below exceptions:
To avoid having to replicate all the work you have done for example for an ongoing submission, the 32Bit version remains still available for some time.
- Due to the change to the 64bit infrastructure, the randomness of simulations has changed which means that simulations that are executed on the new system will present slight (random) deviations towards outcomes generated on the current versions. The magnitude of random variability is dependent on the simulation size (i.e. declines with increasing number of patients and/or bootstrap iterations included).
- The web interface appearance has changed slightly. Since the upgrade to 64 bit required a reimplementation of the web code, we took advantage of this update to change particular features which are explained in the attached update guide.
To access the 32bit versions, please use the following URL links:
CDM v9.0: http://www.core-diabetes.com:8080/login.asp
CDM v8.5: http://www.core-diabetes.com:8080/CDM2012/login.asp